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28 Powerful Prayers for Anxiety and Depression

28 Powerful Prayers for Anxiety and Depression

Prayers for anxiety and depression will help you in your time of great difficulty. Difficult circumstances in life can cause you to feel anxious and depressed.

This happens when you don’t know how to handle some situations that threaten your life.

Prayers for Anxiety and Depression

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According to an article on, anxiety, and depression stem from attempts to control either the future (through worrying) or the past (by trying to change what has happened).

Billy Graham said anxiety is the natural result when our hopes are centered on anything short of God and his will for us.

God’s word directs us to pray over everything instead of worrying about any situation (Philippians 4:6-7).

The result of praying instead of worrying is the promise of God’s peace that surpasses all understanding. It guards your heart and mind and this keeps you from anxiety and depression.

Below are 13 prayers for anxiety and depression.

1. Prayer for God’s loving Words.

Proverbs 12:25 “Anxiety in the heart of man causes depression, But a good word makes it glad.”

Lord, I praise you for you are full of glory and majesty. You are my healer and deliverer and I can always count on you to be by my side.

I ask that you fill my mind with your words so that my heart may be glad.

Remove all anxiety from my heart and show me how to trust in you day by day. Help me not to worry about what tomorrow holds but to focus on today, which is the present.

You are in charge of my tomorrow and I know you have good plans for my life.

May the truth in your words fill my heart to overflowing.

In Jesus’ name, I pray. Amen.

2. Prayer to be still and listen to God.

Psalm 46:10 “Be still, and know that I am God.”

Lord, thank you for the solutions for everything I go through in this life. You care about every aspect of my life and want to see me in good mental health.

When my mind is healthy, I can make sound decisions.

Help me to still my mind so I can hear you speaking to me. Your words always uplift my soul and give me hope for a better life.

Teach me to quiet my mind daily and identify your still small voice.

Give me the discernment I need to identify your voice from that of the stranger. I want to follow what you are saying to me.

In Jesus’ name, I pray. Amen.

3. Prayer to discern the presence of God.

Isaiah 41:10 “So do not fear, for I am with you; do not be dismayed, for I am your God. I will strengthen you and help you; I will uphold you with my righteous right hand.”

Lord, I praise you because you are my helper and deliverer. Today I ask you to help me discern your presence in my life.

You promised that you are always with me at all times. I don’t have to fear because you are always watching over me.

Strengthen me to face each day without fear and anxiety. Help me overcome my depressing thoughts and only allow positive ones in my mind.

May your light shine on my path that I will see where I am going with clarity.

In Jesus’ name, I pray. Amen.

4. Prayer for renewal of Hope.

Psalm 42:11 “Why, my soul, are you downcast? Why so disturbed within me? Put your hope in God, for I will yet praise him, my Savior and my God.”

Lord, my days are full of darkness. My soul is downcast and I have a hard time keeping my head up.

Come to my rescue and deliver me from the anxiety and depression I feel. They weigh me down every day and that makes me not want to face the world.

I will put my hope in you from this day forward. My eyes will be on you and your mighty power. Your praise will be on my lips and I will remember that you are my savior.

I will not allow disturbing thoughts to fill my mind but only those that build me up.

In Jesus’ name, I pray. Amen.

Also Related: 15 Prayers for Protection from- Enemies.

5. Prayer for casting out a spirit of Fear.

2 Timothy 1:7 “For God has not given us a spirit of fear, but of power and of love and of a sound mind.”

Lord, you said you have not given me a spirit of fear, and today I cast it out of my life. I refuse to partner with the fearful thoughts it brings to my mind.

My mind is holy ground and I will only allow thoughts that are pleasing to you.

Forgive me for when I gave in to fear instead of trusting in you. Help me come to you in prayer instead of worrying about anything.

I reject anxiety and depression and declare they will not prevail over my mind.

I will guard my mind because I know the power it has over my life.

In Jesus’ name, I pray. Amen.

Anxiety and Depression

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6. Prayer to trust in the Lord.

Proverbs 3:5-6 “Trust in the Lord with all your heart, And lean not on your own understanding; In all your ways acknowledge Him, And He shall direct your paths.”

Lord, thank you because you are my hope and salvation. You have given me life and have sustained me all these years.

Forgive me when I try to make sense of many things in my life instead of trusting in you.

Show me how to trust in you on my darkest days when I’m surrounded by doom and gloom.

I know that you are the one with the truth and I can trust you to show it to me in every situation.

Help me stop worrying about the future but know that you are in control of it.

In Jesus’ name, I pray. Amen.

7. Prayer to be anxious over nothing.

Philippians 4:6-8 “Be anxious for nothing, but in everything by prayer and supplication, with thanksgiving, let your requests be made known to God; and the peace of God, which surpasses all understanding, will guard your hearts and minds through Christ Jesus.”

Lord, your word has a solution for everything I face in life. Instead of worrying and being anxious, I will pray over everything that troubles me.

Today I hand over to you every situation that troubles me and trust that you can solve it.

I ask that you help me with the challenges I face in my family, work, goals, and relationships.

May your peace that surpasses all understanding guard my heart and mind and keep me from anxiety and depression.

In Jesus’ name, I pray. Amen.

8. Prayer for deliverance from oppressive thoughts.

Psalm 9:9 “The Lord also will be a refuge for the oppressed, A refuge in times of trouble.”

Lord, I struggle with oppressive thoughts that leave me feeling anxious and depressed. My attempts to overcome them have failed. I come to you because you know how to help me.

Deliver my mind from dark thoughts that steal my joy. I take refuge in you because you are my strength. Teach me how to guard my mind and not allow thoughts that are not of you.

Help me check every thought against your word and let go of those that don’t align with it. I will fill my mind with hopeful thoughts that leave me feeling positive.

In Jesus’ name, I pray. Amen.

Also Related: How to get your Prayers Answered a Helpful Guide.

9. Prayer to cast your cares on the Lord.

1 Peter 5:6-7 “Therefore humble yourselves under the mighty hand of God, that He may exalt you in due time, casting all your care upon Him, for He cares for you.”

Lord, thank you for always caring for me and showering me with your unfailing love. You are a loving Father and care about every aspect of my life, even the little things.

Your concern for my affairs comforts me because I know you will never leave nor forsake me.

I place myself under your care and trust that you will care for my needs. Help me not to worry about them because you have promised to provide for me.

I don’t have to worry and be anxious about how you will meet them.

In Jesus’ name, I pray. Amen.

10. Prayer against worry.

Matthew 6:34 “Therefore do not worry about tomorrow, for tomorrow will worry about itself. Each day has enough trouble of its own.”

Lord, you are the God who has a plan for my life. It is a plan to give me a future and hope. I don’t have to worry because my life is in your hands.

You are in charge of my life and I will not worry about how it will turn out.

Help me not to worry about the troubles of today but to know you will help me handle them. You give me strength for each day and fill my life with your blessings.

Worry cannot add a day to my life and I banish it from my mind.

In Jesus’ name, I pray. Amen.


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11. Prayer against a troubled Heart.

John 14:1 “Do not let your hearts be troubled. You believe in God; believe also in me.”

Lord, you always comfort me when I go through troubling times. You have promised to deliver me from all my troubles so I may live an abundant life.

My heart is troubled today because of the issues in my life. I don’t know how to deal with them and I am filled with troubling thoughts.

I will believe in your mighty power to save me because you are my savior. You are my strength and hope and because of you, I can look forward to better days.

Help me trade my troubling thoughts with your word which is the truth. I will guard my heart against evil.

In Jesus’ name, I pray. Amen.

12. Prayer for a Cheerful Heart.

Proverbs 17:22 “A cheerful heart is good medicine, but a crushed spirit dries up the bones.”

Lord, I praise you because you are all-knowing and all-powerful. There is no other God like you. My spirit is crushed because of many things happening in my life.

I feel hurt and depressed and don’t know where to turn for help.

My eyes are on you because you are the only one who can help me get through the pain I feel. Give me a cheerful heart that will bring health to my mind and body.

My troubles have made me feel weak and afraid. May your words bring health to me and fill me with cheer.

Grant me your joy and gladness so I will walk with confidence knowing all shall be well.

In Jesus’ name, I pray. Amen.

13. Prayer for joy in your Spirit.

Philippians 4:4 “Rejoice in the Lord always. I will say it again: Rejoice!”

Lord, thank you for helping me whenever I have struggles and challenges. It is hard for me to feel your joy because of a heavy heart.

Today I ask you to help me rejoice despite the things I am going through in my life.

Grant me the grace to rejoice knowing my troubles will be gone tomorrow. You promised that you will make all things work together for my good.

That’s enough to make me rejoice because you have defeated the enemy in my life.

In Jesus’ name, I pray. Amen.

14. Prayer to Calm Your Anxiety.

Psalm 23:4. Even though I walk through the valley of the shadow of death, I will fear no evil, for you are with me; your rod and your staff, they comfort me.

Heavenly Father, the one who knows and loves me. I need you more than ever in this moment of my ordeal.

You created me and your thoughts towards me have always been for good and never an iota of hurt. I give you the freedom to do what You want with my rumbling mind, my unhappiness, and constant panic.

Dear Lord, I ask that you heal me from every anxiety, help me to be calm even in the raging storms. Help me to find peace and joy in you and your word.

Do what you want for me and help me attain the peace and happiness that you have always had in store for me right from the foundation of the world.

I am grateful because you know me in and out and even with my baggage, you still love me. In Jesus’ Name, amen.

15. Prayer to Experience God’s Love and Care.

1 John 4:18. Such love has no fear because perfect love expels all fear. If we are afraid, it is for fear of punishment, and this shows that we have not fully experienced His perfect love.

Dear God, help me come into the knowledge that you love me. Hold me in your warm embrace and let me feel your peace and warmth.

I am not afraid even with the darkness around me, I am confident that your light is shed abroad in my heart, mind, and soul. May I find solace and peace in your love and the consciousness that I am your own?

Lord, even in the midst of my stress, panic, apprehension, and suffering, please help me to keep my gaze fixed on you.

When negative and scary thoughts try to cloud my mind, remind me to always keep my mind stayed on you. I give you permission to help me see where you are working in me, and may I find joy and encouragement always in You.

In the Name of Jesus, Amen.

16. Prayer for Peace and Relief from Anxiety.

2 Thessalonians 3:16. Now may the Lord of peace himself give you peace at all times in every way. The Lord be with you all.

Lord Jesus Christ, I ask that you flood my heart with peace that passes all understanding. Help me to lose hold of my fruitless attempts to figure things out.

Almighty God, help me to trust the process of resting on your perfect peace. I pray that I find the needed wisdom to make the right decisions that will bring a harvest of righteousness in my life.

Lord, I make a decision to trust You and use Your peace as my guard. Impart in me the ability and willingness to cast all my anxiety on you, because I know You have me in mind always. In Jesus’ Name, Amen.

17. Prayer to Lighten the Burden.

Philippians 4:6. Do not be anxious about anything, but in every situation, by prayer and petition, with thanksgiving, present your requests to God.

Abba Father, I have borne this burden for too long. My present sin has wrecked my heart. My past guilt has crippled my obedience.

Anxiety over things beyond me has overwhelmed my soul and I am tired. I come to You Lord, seeking to partner with You, please take my load, lighten my burden that my heart may find rest. In Your name. Amen.

18. Prayer to Replace Struggle with Joy.

Psalm 16:11 – You make known to me the path of life; in your presence, there is fullness of joy; at your right hand are pleasures forevermore.

Heavenly Father, you alone know my deepest secrets and are able to reach the farthest places within my heart. Lord, I feel drained, overwhelmed, and unworthy of Your love.

Help me to truthfully submit the things that keep me captive inside my heart. Exchange my struggle with Your joy. I reclaim my joy and position beside You. Consume me in Your joy for in You is where my strength is found.

In Jesus’ Name, Amen.

19. Prayer for peace for the Overwhelmed Heart.

John 14:1 Let not your hearts be troubled. Believe in God; believe also in me.

O Lord my Father, when my heart is overwhelmed and filled with uncertainty and restlessness, let your floodgates be open on me, and let your peace sweep into every crevice within my heart. Lead my heart to You, my rock and pillar. Let Your Word be my strength and refuge.

May I do not cling to things that don’t matter, but lead me to what truly matters? Let me forever be conscious of placing everything under your will, make it my habit.

I appreciate you for everything you do, is for a reason and a purpose. Thank you for even when I am weary and downtrodden, your promised rest and peace for my soul will come. This, I am assured of by your word.

Your spirit refreshes, fills, and equips me with joy and is a shield and hope in troubling times. Equip me with sensitivity to discern and take notice of others who seem weary and burdened too.

Help me to slow down, to take the time, and to be a light to others. Help me to be a source of succor and relief to them. In Jesus’ Name, Amen.

20. Prayer for Faith Instead of Fear and Worry.

Psalm 34:4–5. I sought the Lord, and he answered me and delivered me from all my fears. Those who look to him are radiant, and their faces shall never be ashamed.

Almighty and Everlasting Father, have mercy on me when I succumb to fear and worry rather than stepping out with the whelps of faith and trusting You.

I begin to gain mastery in capturing the right thoughts and focusing on You. Though my faith might be as little as a mustard seed, and brittle as stubble, I decide intentionally to place it in You. In Jesus’ Name, Amen.

21. Prayer for Brave Faith in Scary Times.

Deuteronomy 31:8 – He will never leave you nor forsake you. Do not be afraid; do not be discouraged. When you’re fearing a situation or emotional challenge, really envision God saying this, just to you. He’s on your side.

Dear God, your spirit of boldness, braveness, and courage, just like those of the Apostles is all I need today. I replace every fear with faith and I ask that your wisdom overshadows my life.

Fill me with Your love, joy, and peace instead, Lord. In Jesus’ name, Amen.

22. Prayer to Overcome Panic Attacks.

Deuteronomy 31:6– Be strong and courageous. Do not fear or be in dread of them, for it is the Lord your God who goes with you. He will not leave you or forsake you.

Dear Lord, thank you for always being mindful of me, my soul leaps for joy when I think of your goodness. But my spirit is troubled, my soul is distressed and depressed and my body is weak. I cannot bear the weight of this anxiety and panic any longer.

Dear Lord, I acknowledge that I need you and I pray against every enemy trying to trample on my faith and tear me apart. I will stand strong in you till the end when I will become fortified in every weary place.

Father, I am confident in your promise that this too shall pass. I am filled with your joy, peace, and perseverance.

My soul is restored and I break loose from every chain of anxiety, panic, and depression. I declare that I am no longer a slave to fear but my confidence is hinged on you. In Jesus’ Name, Amen!

23. Prayer for Freedom from Stress.

Isaiah 41:10. So do not fear, for I am with you; do not be dismayed, for I am your God. I will strengthen you and help you; I will uphold you with my righteous right hand.

Dear Lord, I believe in your promise of supernatural healing, and I believe that it is in your power alone to heal. On this confidence, I stand, and in this assurance, I bask.

I begin to spend time studying the Word and praying. Set me free from my distress and from the grave. I am grateful because you care for me and I know that you can set me free from every heavy load of stress and depression that makes an attempt to overwhelm my soul.

In Jesus’ Name, Amen.

24. Prayer for Hope When Trusting God is difficult.

Exodus 15:2 The Lord is my strength and my song; he has given me victory. This is my God, and I will praise him my fathers God, and I will exalt him!

Heavenly Father, sometimes it is hard to trust you because it seems that there might be a delay in answers to my prayers. But help me never to doubt You on any ground or for any reason.

Help me to keep my mind stayed on you: trust you. I am equipped with divine wisdom to handle situations weighing me down, and help me release my burdens to You. Thank You for Your absolute love. In Jesus’ Name, Amen.

25. Prayer for Battling Depression.

Deuteronomy 31:8– The Lord himself goes before you and will be with you; he will never leave you nor forsake you. Do not be afraid; do not be discouraged.

Dear Heavenly Father, thank you for you never change. Lord, everything around me can change and is unpredictable but you remain the same.

Satan’s scourge has confronted my soul, attempting to overwhelm me, but I trust you to sustain, protect, and enable me to remain steadfast.

Since sin entered the world, all creation struggles, and groans; this is why struggles abound physically, emotionally, and spiritually. But Lord, help me to triumph over my circumstances.

I shut down every spirit of depression, pain, angst, and heartbreaking experiences. I declare my victory with a loud roar and rise from every bondage that easily besets me. In Jesus’ Name, Amen.

26. A Prayer When You’re in Darkness.

Isaiah 42:16– I will lead the blind by a way they do not know, In paths, they do not know I will guide them. I will make darkness into light before them And rugged places into plains. These are the things I will do, And I will not leave them undone.

Almighty Father, there is so much darkness around me, but help me find my way back to your light. Taking my own life seems like the best option at this point but I trust you to make a way of escape.

Lord, I ask that only your light shines in the darkness that has overtaken me. I release myself from every thought of death and all the lies that the devil tells me; I keep your word of truth before me as a reminder.

The consciousness that I have you and that you are my strength and buckler engulfs my life now and always. In Jesus’ Name, Amen.

27. A Prayer for Escaping the Pit of Depression.

Philippians 4:6 – And the peace of God, which surpasses all understanding, will guard your hearts and your minds in Christ Jesus.

Lord, rescue me from every deep pit that I have fallen into. The pain, suspense, hurt and distress, and rejection have thrown my neck deep into a pit.

Lord, I am helpless and afraid; rescue me out of this pit and lead the way, Lord. In Jesus’ name, Amen.

28. Prayer to Overcome Anxiety and Depression.

Proverbs 15:13A joyful heart makes a cheerful face, but when the heart is sad, the spirit is broken.

Heavenly Father, thank You for giving me victory for every struggle that poses a stumble on my way. You have overcome the world and you have given me the power and grace to overcome too.

Give me the grace to rise above my circumstances. I cast all my care on You because I know You care for me. Strength is made available for me to win and overcome.

You are a God of order and there is no confusion in you; I ask that you order my life and lift burdens off my heart. Thank You for giving me the victory In the

Mighty Name of Jesus, Amen!

In closing

You can overcome anxiety and depression with God’s help. He has the solutions for what you are worrying about all day.

According to Laurie Coombs, when we let the light of Christ shine into our hearts and minds, we will most definitely see darkness flee.

Prayers for Anxiety and Depression Resources.

Below are books you can read on how you can deal with the anxious and depressing thoughts you feel.

  1. Overcoming Anxiety and Depression by Bob Phillips
  2. When the Darkness Will Not Lift by John Piper
  3. Battlefield of the Mind by Joyce Meyer
  4. Spurgeon’s Sorrows by Zack Eswine

Here’s an inspiring quote on anxiety.

“Anxiety does not empty tomorrow of its sorrows, but only empties today of its strength.”

~ Charles Spurgeon

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