Prayers for Depression and Loneliness: 15 Helpful

By David •  Updated: 05/02/22 •  10 min read

Depression is an emotional illness that sets the human mind in a sorrowful state.

Loneliness, on the other hand, breeds sadness and low self-esteem. Both of these emotional issues can damage the mental state of an individual in the long run.

We need to deal with these toxic emotional state of mind using effective prayers for depression and loneliness.

However, if you’re suffering from the aforementioned emotional traumas, please don’t give up on the hope of full recovery. Know that God can rescue you from afflictions, depression, and loneliness.

Also, if you have a loved one, family member, or friend battling these, do well to intercede on their behalf by praying the prayers for depression and loneliness below with faith.

Here are Prayers for depression and loneliness.

  1. A Prayer for Depression.

2 Samuel 22:29 (NIV) – You, Lord, are my lamp; the Lord turns my darkness into light.

Faithful God, thank you because you are still on the throne, a greater throne than all. Thank you, too, because I have you; hence, I will overcome every situation that’s making me depressed.

Lord, it’s with this that I cry to you to set me free from this darkness. And bring me to your light, the light of peace, contentment, and joy, so that I will live happily as your child that I am.

In Jesus’ name, I pray, Amen.

  1. Prayer for Loneliness and Depression.

Matthew 11:28-30 (NIV) – Come to me, all you who are weary and burdened, and I will give you rest.

Take my yoke upon you and learn from me, for I am gentle and humble in heart, and you will find rest for your souls, for my yoke is easy, and my burden is light.

Heavenly Father, I have come to you with a weary and burdened heart, but I know that your love for me will see me through. I ask that you use this love to free me from this emotional prison.

Grant me peace of mind and rest, dear God. Cause your overwhelming light to deliver me from this spirit of loneliness and depression.

Above all, Father, fill my heart and spirit with hope, joy, and peace.

In Jesus’ name, Amen.

  1. Prayer for Postpartum Depression.

Isaiah 41:10 (NIV) – So do not fear, for I am with you; do not be dismayed, for I am your God. I will strengthen you and help you; I will uphold you with my righteous right hand.

Dear God, I appreciate you for being with me during the difficult period of pregnancy and delivery. I ask that you strengthen me for this postpartum.

Dear Father, I want to be the best mother to my baby; please help me get over the stress of being a nursing mother.

Please help me understand my husband, too, and how to treat him, especially in this time of depression. Though I’m slowly losing a sense of hope, I ask that you uplift my spirit.

Please give me the strength to overcome this state and become stronger than ever. In Jesus’ name, Amen.

  1. Prayer for Your Loneliness.

Romans 8:38-39 (NIV) – For I am convinced that neither death nor life, neither angels nor demons, neither the present nor the future, nor any powers,

neither height nor depth, nor anything else in all creation, will be able to separate us from the love of God that is in Christ Jesus our Lord.

Almighty God, thank you because you can heal those afflicted and deliver those in trouble. Hence, I run to you because I’m troubled and lonely.

Precious Holy Spirit, I have come to seek your help once more. Be my companion and strengthen me to overcome this period of isolation and the grace to live a healthy life.

In Jesus’ name, Amen.

  1. Christian Prayer for Healing Depression.

John 16:33 (NIV) – I have told you these things, so that in me you may have peace. In this world, you will have trouble. But take heart! I have overcome the world.

Precious Lord, you are a good God because your remarkable deeds speak volumes. Even though the world is ravaged by all manners of trouble, I’m not despondent because your power still reigns.

Almighty God, I pray that you deliver me from my present predicament. Give me the heart to overcome this feeling that I don’t completely understand, and in turn, I will continue to worship you, dear Lord.

Thank you because I know you will grant my request.

In Jesus’ name, Amen.

Also Related: 15 Powerful Prayers to Get Out of Depression.

  1. Deliverance Prayer for Depression.

Psalm 143:7-9 (NIV) – Answer me quickly, Lord; my spirit fails. Do not hide your face from me, or I will be like those who go down to the pit.

Let the morning bring me word of your unfailing love, for I have put my trust in you. Show me the way I should go, for to you, I entrust my life. Rescue me from my enemies, Lord, for I hide in you.

Sovereign Lord, I’m grateful to you for your grace that’s always sufficient for Me. Thank you too for your word that says that whoever puts their trust in you is never disappointed.

This is why I rely on you at all times, especially in my time of need, such as now.

Please deliver me from this sadness, restlessness, discontentment, and all the negative emotions that I can’t even explain. And help me find fulfillment.

Lastly, reset my mind towards gratitude, love, and happiness.

In Jesus’ name, Amen.

  1. Healing Prayer for Depression.

Psalm 9:9 (NIV) – The Lord is a refuge for the oppressed, a stronghold in times of trouble.

Dear Lord Jesus, thank you in advance because I don’t doubt that you will restore my hope and will to live. Strengthen me from every weakness and heal my troubled heart.

Set me free from feelings of despondency, sorrow, and worries. Instead, heal and restore my troubled soul while and fill me with your peace.

In Jesus’ name, Amen.

  1. Prayer for a Friend Battling Depression.

Psalm 40:2 (NIV) – He lifted me out of the slimy pit, out of the mud and mire; he set my feet on a rock and gave me a firm place to stand.

Everlasting Father, thank you so much for the life of my friend. Even though he seems to be dejected most of the time, I know you are doing a new thing in his life.

Lord, you know of his struggles with depression, gloom, and despair; and I know that you are the only one who can truly help him.

So, I ask that you please help him overcome these struggles. Touch him with your healing touch and restore him to normalcy.

In Jesus’ name, Amen.

  1. Prayer for Bipolar Depression.

Psalm 34:17-18 (NIV) – The righteous cry out, and the Lord hears them; he delivers them from all their troubles. The Lord is close to the brokenhearted and saves those who are crushed in spirit.

Abba Father, your grace is sufficient enough to comfort me. Hence, I come to you because I know you are always there to listen to the cry of the heartbroken.

My present condition has made me unhappy and unable to socialize like I used to. That’s why I ask that you restore my sanity and heal my broken heart as well. Assist me in being the person you created me to be.

In Jesus’ name, Amen.

  1. Prayer for a Child Battling Depression.

Isaiah 40:31 (NIV) – But those who hope in the Lord will renew their strength. They will soar on wings like eagles, they will run and not grow weary, they will walk and not be faint.

Our Father in Heaven, at this point, I’m helpless as a parent because of my little child who is battling depression.

I earnestly pray that you have mercy on him because he doesn’t even understand what’s happening to him. Grant him the strength to overcome the despair, sadness, loneliness, fear, and pain that he feels.

Lord, you renew lost hopes. Therefore, I ask that you lay your hand on my child and restore my baby to wholeness.

In Jesus’ name, Amen

Also Related: 28 Powerful Prayers for Anxiety and Depression.

  1. Prayer for Fear and Loneliness.

1 Peter 5:6-7 (NIV) – Humble yourselves, therefore, under God’s mighty hand, that he may lift you in due time. Cast all your anxiety on him because he cares for you.

Omnipotent God, your word tells me that you have not given me the spirit of fear. I also know that you don’t want me to be lonely.

That’s why I know that even though my spirit is down, I trust that you will uplift me and fill me with confidence.

Father Lord, your word has made me understand that there’s no need to fear the evils of this world because you are with me. I beg for the grace to overcome these trying times and experience peace and fulfillment.

In Jesus’ name, Amen.

  1. Prayer for Grief and Loneliness.

Jeremiah 29:11 (NIV) – For I know the plans I have for you,” declares the Lord, “plans to prosper you and not to harm you, plans to give you hope and a future.

Gracious God, recent happenings in my life have suddenly filled me with anguish, sadness, and loneliness. This is why I humbly ask that you take complete charge of my life.

Father, remove every spirit of doubt, fear, and loneliness from me and exact your plans for me.

Above all, let your presence overshadow my feelings, thoughts, and actions.

In Jesus’ name, Amen.

  1. Prayer for Sadness and Loneliness.

Psalm 145:18-19 (NIV) – The Lord is near to all who call on him, to all who call on him in truth. He fulfills the desires of those who fear him; he hears their cry and saves them.

Holy God, the Scripture tells me that you are near to all who call on you and to all who call on you in truth. You also fulfill the desires of those who fear you, and you hear their cry and save them.

So, I ask that you help me in the same way, change my mourning to laughter and my sorrows to joy.

In Jesus’ name, Amen.

  1. Prayers for Deep Despair.

Isaiah 43:2 (NIV) – When you pass through the waters, I will be with you; and when you pass through the rivers, they will not sweep over you. When you walk through the fire, you will not be burned; the flames will not set you ablaze.

Most High God, things seem not to be going well for me these days. I find myself worrying and sad as a result of this, but I’m consoled because I know that you can heal me of these gloomy and hollow feelings.

You promised to be with me when I pass through the waters and that when I pass through the rivers, they will not sweep over me. Likewise, I request that you save me from this deep despair that’s threatening to overtake me.

In Jesus’ name, Amen

  1. Prayers for Sad Times.

1 Peter 5:7 (NIV) – Cast all your anxiety on him because he cares for you.

Sovereign Lord, I’m currently experiencing bad situations that have left me feeling very sad. But, your word commands us to cast all our cares on you.

So, I look to you to help me and replace every sad feeling in my heart with joy that only comes from you.

Also, fill my mind with the peace that nothing can threaten or steal.

In Jesus’ name, Amen.

Conclusion

The greatest cure for loneliness and depression comes from the Holy Spirit. So, as you pass through this difficult time, use these prayers for depression and loneliness provided in this article to take hold of your liberation.

Furthermore, you can also use the same prayers for your loved ones suffering from the aforementioned afflictions to bring them to God’s light.

David

Is an Ordained Minister and Life Coach. He is an ordained minister since 1988. Shortly after receiving Jesus as his personal savior, he answered the call to ministry.